Prophylaxis of intravaginal HIV infection
Tenofovir was investigated in the postexposure prophylaxis (PEP) of intravaginal infection of pig-tailed macaques with HIV-2.
Tenofovir was administered subcutaneously at 30 mg/kg for 28 days starting 12, 36 or 72 h after viral inoculation.
Early intervention (i.e. treatment started at either 12 or 36 hours after viral inoculation) prevented HIV infection via vaginal exposure.
Otten et al., J. Virol. 74, 9771-9775 (2000)