Prophylaxis of perinatal HIV infection
Tenofovir protects newborn macaques against oral SIV infection.
By the age of 3 days, newborn macaques were inoculated orally with virulent SIVmac251.
Tenofovir was administered subcutaneously at 2 doses of 4 mg/kg either 4 h before or 20 h after, or 1 and 25 h after, or as a single dose of 30 mg/kg at 1 h after SIV inoculation.
The animals remained SIV negative and seronegative.
Van Rompay et al., J. Infect. Dis. 184, 429-438 (2001)