Prophylaxis of parenteral HIV infection
Tenofovir protects macaques against intravenous SIV infection.
Juvenile, long-tailed macaques were inoculated intravenously with SIVmne.
Tenofovir was administered subcutaneously once daily beginning either 48 hours before, 4 hours after or 24 hours after virus inoculation. Treatment continued for 4 weeks.
Tenofovir prevented SIV infection in all macaques without toxicity, whereas all control macaques became infected.
Tsai et al., Science 270, 1197-1199 (1995)