PPT Slide

Das et al., J. Virol. 75: 4771-4779 (2001)

Interaction of 3TCTP (lamivudine triphosphate) with YMDD region

of HBV DNA polymerase

Binding of 3TCTP to wild-type (left) and Met552Val mutant (right) HBV DNA polymerase. Molecular modeling suggests

that steric hindrance (right) between 3TCTP and the mutated amino acid, Val552, is the primary cause of 3TCTP

resistance. This steric conflict is not observed in the binding of 3TCTP to the wild-type HBV polymerase.

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