PPT Slide

Interaction of dCTP with YMDD region of HBV DNA polymerase

Das et al., J. Virol. 75: 4771-4779 (2001)

Amino acids Met552 and Leu528 are mutated to confer resistance to 3TC and FTC. The orange molecular surface

(left) corresponds to the deoxyribose of the docked dCTP. The green molecular surface of the protein around its

YMDD region (left) indicates no steric hindrance between the protein and the substrate. The space between the

two molecular surfaces is indicated by a white arrow. The space between the protein and substrate is reduced

upon Met552Val + Leu528Met mutation (right).

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