AMPHOTERICIN-B VERSUS ITRACONAZOLE iv --> solutionAS EMPIRIC THERAPY FOR REFRACTORY FEBRILE NEUTROPENIABoogaerts: investigators meeting ITR-INT-62 Janssen 1998

AMPHO-B

ITRACONAZOLE

RESPONSE

DOCUMENTED

FUNGAL INFECTION

ADVERSE EVENTS

drug cessation

POTASSIUM SUPPLETION

37%

4%

58%

75%

48%

4%

42%

69%

0.7-1 mg/kg/24 hrs

n = 130

200mg 2-4x daily, 2-12 days iv

200mg 2x daily, max 14 days

n = 127

40% 21%

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