AMBISOMEŽ VERSUS AMPHOTERICIN-B  AS EMPIRIC THERAPY FOR REFRACTORY FEVER WALSH et al, N Engl J Med 1999;340:764

AMPHO-B

DEFERVESCENCE

BREAKTHROUGH

FUNGAL INFECTION

DEATH DUE TO

FUNGAL INFECTION

FEVER / CHILLS

NEPHROTOXICITY

58%

8%

3%

54 / 74%

34%

0.6 mg/kg/24 hrs

n = 344

3 mg/kg/24 hrs

n = 343

AMBISOME

58%

3%

1%

17 / 38%

19%

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