Paramètres de l’efficacité des b-lactamines
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-
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Porin channel
Outer membrane
Cell
membrane
Gram
negative
cell wall
Periplasmic
space
High affinity
for PBPs
Low affinity
for beta
lactamases
PBPs
Beta-lactamases
Bullet-shaped
zwitterion
oriented
by electrical
charge
Rapid penetration
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