ITRACONAZOLE VERSUS FLUCONAZOLEAS PROPHYLAXIS DURING NEUTROPENIAMORGENSTERN et al, Brit J Haematol 1999

ITRACONAZOLE

SOLUTION

FLUCONAZOLE

SUSPENSION

SYSTEMIC FUNGAL INFECTION

FATAL ASPERGILLUS

I.V. AMPHOTERICIN B

ADVERSE EVENTS

vomiting

diarrhoea

hypokalaemia

COMPLETED STUDY WITHOUT

FUNGAL INFECTION

3.5%

0%

14%

37%

57%

21%

40%

p = 0.04

200 mg/24hrs

n = 288

100 mg/24 hrs

n = 293

OPEN,

RANDOMISED

4.5%

1.5%

20%

23%

34%

9%

48%

p = 0.001

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