Les nouveaux antibiotiques respiratoires: pour quoi et pour qui ?

Table of Contents

Les nouveaux antibiotiques respiratoires:pour quoi et pour qui ?

Qui sommes nous ?

Qui sommes nous ?

De quoi allons nous parler ?

Quelles ont été nos sources pour cet exposé ?

Plan de l’exposé

Discovery

Why a new “pneumococcal killer” macrolide ?

PPT Slide

En route to a macrolide active against erythromycin-resistant pneumococci ...

How does erythromycin act … and fail in pneumococci ...

Narbomycin ...

From narbomycin to HMR 3004 ...

RU 64004 / HMR 3004 : the first candidate

Telithromycin (RU66647/HMR 3647): key differences with erythromycin A

Activity of telithromycin vs erythromycin as observed during early studies

In vitro activity of telithromycin vs erythromycin as submitted to the FDA (April 2001)

Pharmacokinetics of telithromycin as submitted to the FDA (April 2001)

Pharmacodynamics of telithromycin (as based on FDA submission; april 2001)

Discovery

Fluoroquinolones: the issues ...

Fluorqouinolones: the pharmacophore ...

Fluorqouinolones: how to improve activityand control (some) toxicity ...

Bay y3118 ...

Bay y3118 ...

Moxifloxacin (BAY 12-8039) ...

Moxifloxacin activity as submitted to the FDA...

Pharmacokinetics of moxifloxacinas submitted to the FDA

Pharmacodynamics of moxifloxacin(as based on FDA submission)

Which indications in Europe … and in Belgium * ?

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Conclusions of the "Commission de transparence" for telithromycin (1/3) *

Which are the sensivities of S. pneumoniae towards telithromycin in Belgium in 2000 ?

Sensibilités selon Aventis-Belgium...

Pour le futur ...

Conclusions of the "Commission de transparence" for telithromycin (2/3) *

Conclusions of the "Commission de transparence" for telithromycin (3/3) *

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Review of the clinical studies submitted to the Belgian "Commission de transparence"

Conclusions of the "Commission de transparence" for moxifloxacin (1/2) *

Which are the sensitivities of S. pneumoniae towards moxifloxacin in Belgium in 2002 ?

Conclusions of the "Commission de transparence" for moxifloxacin (1/2) *

Et qu'y a-t-il de nouveau * depuis le remboursement ?

Et qu'y a-t-il de nouveau depuis le remboursement ?

Pour quoi et pour qui ?

Pour quoi et pour qui ?

Pour quoi et pour qui ?

Ask for more in the future …

Ask for more in the future …

Price comparisons (in Belgium) ...

A bit of pharmacoeconomics ...

Please, ask questions ...

Email: seminf@facm.ucl.ac.be

Home Page: http://www.md.ucl.ac.be/seminfect/resume.htm

Other information:
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