Fluoroquinolones: the issues ...
1st and 2d generation (norfloxacin, ofloxacin, pefloxacin, ciprofloxacin) were poorly active against Streptococci, and S. pneumoniae in particular, and therefore, did not receive indications in this area ...
the development of “respiratory” fluoroquinolones has met with major toxicity problems … and marketing withdrawals