From narbomycin to HMR 3004 (the first ketolide)...

5S rRNA

V

Erythromycin A

2058

O

O

• By adding a side chain in C11-C12, it becomes possible for narbomycin-like compounds to bind to domain II …

• the molecule gains in activity, AND

• remains unsensitive to the Erm mechanism of resistance

II

752

erm

Synthesis of erythromycins as bactericides. Agouridas, Constantin; Benedetti, Yannick; Chantot, Jean-Francois; Denis, Alexis; Le Martret, Odile. (Roussel-UCLAF, Fr.). Eur. Pat. Appl. (1995), 28 pp. CODEN: EPXXDW EP 676409 A1 19951011

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