Quinolone Activity Against Ciprofloxacin-Resistant S. pneumoniae*

4

4

4

16

32

MIC (?g/mL)

MIC (?g/mL)

Isolates Inhibited (Cumulative %)

ɘ.03

0.06

0.12

0.25

0.5

1

2

4

8

16

32

64

ɘ.03

0.06

0.12

0.25

0.5

1

2

4

8

16

32

64

*Resistance to ciprofloxacin defined as ?4 ?g/mL. Yellow arrow = MIC90 in wild type strains

Adapted from Chen et al. N Engl J Med. 1999. White Bar = MIC90 in cipro resistant strains

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