PPT Slide

Macrolide-resistant S. pneumoniae

- BELGIUM methylation of ribosomal RNA (erm B gene): 92 %

efflux (mef E gene): 3 %

both (erm B gene + mef E gene): 5 %

J Antimicrob Chemother 2000; 45: 119-121.

• USA mostly efflux mechanism

RESISTANCE MECHANISMS

MIC efflux << MIC ribosomal :

In Belgium: macrolide resistance = treatment failure

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