PPT Slide

Acyclic nucleotide analogues

Acyclic nucleoside phosphonates

Cidofovir

(HPMPC)

R = H: Adefovir (PMEA)

R = (CH3)3C-CO-O-CH2-:

Adefovir dipivoxil

Bis(POM)-PMEA

R = H: Tenofovir (PMPA)

R = (CH3)2CH-O-CO-O-CH2-:

Tenofovir disoproxil

Bis(POC)-PMPA