PPT Slide
Milestones (keynote papers) in the development of adefovir
R. Pauwels, J. Balzarini, D. Schols, M. Baba, J. Desmyter, I. Rosenberg, A. Holư & E. De Clercq.
Phosphonylmethoxyethyl purine derivatives: a new class of anti-human immunodeficiency virus agents.
Antimicrob. Agents Chemother. 32, 1025-1030 (1988).
J. Balzarini, L. Naesens, P. Herdewijn, I. Rosenberg, A. Holư, R. Pauwels, M. Baba, D.G. Johns &
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human
immunodeficiency virus agents.
Proc. Natl. Acad. Sci. USA 86, 332-336 (1989).
J. Balzarini, Z. Hao, P. Herdewijn, D.G. Johns & E. De Clercq.
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)-
adenine, a potent anti-human immunodeficiency virus compound.
Proc. Natl. Acad. Sci. USA 88, 1499-1503 (1991).
T. Yokota, S. Mochizuki, K. Konno, S. Mori, S. Shigeta and E. De Clercq.
Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis.
Antimicrob. Agents Chemother. 35, 394-397 (1991).
L. Naesens, J. Balzarini, N. Bischofberger & E. De Clercq.
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloylmethyl)-9-(2-phosphonylmethoxy-
ethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Antimicrob. Agents Chemother. 40, 22-28 (1996).