PPT Slide
Milestones (keynote papers) in the development of cidofovir
R. Snoeck, T. Sakuma, E. De Clercq, I. Rosenberg & A. Holư.
(S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC]: a potent and selective inhibitor of human cytomegalovirus replication.
Antimicrob. Agents Chemother. 32, 1839-1844 (1988).
J. Neyts, R. Snoeck, D. Schols, J. Balzarini & E. De Clercq.
Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)-guanine (DHPG).
Virology 179, 41-50 (1990).
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice.
Antimicrob. Agents Chemother. 35, 701-706 (1991).
J. Neyts, J. Balzarini, L. Naesens & E. De Clercq.
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxy-methyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice.
J. Med. Virol. 37, 67-71 (1992).
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal
Vaccinia virus infections in severe combined immune deficiency (SCID) mice.
J. Med. Virol. 41, 242-246 (1993).