PPT Slide
Antiviral activity of PMPA first described in 1993
Licensed for clinical use for the treatment of HIV infections
J. Balzarini, A. Holư, J. Jindrich, L. Naesens, R. Snoeck, D. Schols & E. De Clercq.
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphono-methoxypropyl)-2,6-diaminopurine.
Antimicrob. Agents Chemother. 37, 332-338 (1993).