Congo-Crimean hemorrhagic fever

In fact, another Old World VHF virus, Congo-Crimean hemorrhagic fever (CCHF) virus, seems much better suited for biological warfare (BW) than hantaviruses: it can readily be cultivated, is highly infective (although not documented so far by aerosol), and is easily transmissible between humans, giving rise to local epidemics and even to nosocomial infections, putting the nursing personnel at high risk. In contrast to HTV infections, CCHF viremia continues throughout disease until the appearance of antibodies in blood heralds clinical recovery, coinciding with the disappearance of circulating virus. The CCHF-induced case-fatality rate of about 30% is much higher than that of most other VHF infections, and no CCHF vaccine is at hand, or even in the pipeline.

Clement, Antiviral Res. 57, 121-127 (2003)

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