Physicians will be most likely to suspect a filovirus infection if a previously healthy person becomes abruptly ill with high fever, and shows the following signs and symptoms:
hemorrhagic manifestations, perhaps limited to the eyes and mucous membranes;
a maculopapular rash, typically on the trunk, without other skin lesions;
steady worsening of illness to intractable shock, with death within 1 week;
absence of productive cough;
absence of neurologic involvement.
Bray, Antiviral Res. 57, 53-60 (2003)