Viruses as bioweapons: which ones and how to cope with them ?

Chaire Francqui - 13 mars 2003

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Table of Contents

Viruses as Bioweapons:Which ones and how to cope with them

Category A agents of bioterrorism

Category B Agents

Category B Agents (continued)

Variola virus is considered as an ideal bioterrorist weapon for the following reasons:

Contra-indications for vaccination with smallpox vaccine (vaccinia)

Physicians will be most likely to suspect a filovirus infection if a previously healthy person becomes abruptly ill with high fever, and shows the following signs and symptoms:

Effective defense against filoviruses requires a comprehensive approach that includes the following elements:

Viral diseases (VHF) imported into Europe in the recent years

Viruses of the Bunyaviridae family considered of bioterrorism importance

Nipah virus (continued)

Pathogenic hantavirus genotypes

Congo-Crimean hemorrhagic fever

Tick-borne encephalitis virus (TBEV)

TBEV (continued)

Influenza virus

Influenza virus (continued)

IC50 values (µg/ml) for cidofovir against all variola virus isolates tested on Vero cells

Activity of cidofovir (CDV) and HDP-CDV against vaccinia, cowpox, monkeypox and variola viruses

Efficacy and cytotoxicity of acyclic nucleoside phosphonates against vaccinia virus in HFF cells

Activity of (S)-HPMPA analogues against herpes simplex virus (HSV-1, HSV-2, TK- HSV-1) and vaccinia virus (VV) in primary rabbit kidney cells

Author: E. De Clercq

Email: tulkens@facm.ucl.ac.be

Home Page: http://www.md.ucl.ac.be/chaire-francqui/slides

Other information:
These slides are for information only. Do not make public use of them without the autorization of Prof. E. De Clercq and the organizers of the "Chaire Francqui". Please, adress your request to <tulkens@facm.ucl.ac.be>

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