PPT Slide

BAY 57-1293 in the rat lethal challenge model

Lewis rats were inoculated with HSV-1walki intranasally and were treated via

oral gavage t.i.d. from day 0 to day 4 post infection. Five animals for each

group were used.

Betz et al., Antimicrob. Agents Chemother. 46: 1766-1772 (2002)

_?_ Placebo

_?_ Valaciclovir 45 mg/kg

_X_ Valaciclovir 135 mg/kg

_?_ BAY 57-1293 0.5 mg/kg

_?_ BAY 57-1293 2 mg/kg