ARTICLE AUTHOR: Zeegers-F; Gibella-M; Tilquin-B

REPRINT AUTHOR: Zeegers, F; UCL 7230; CHAM, SCH PHARM, AVE MOUNIER 72; B-1200 BRUSSELS; BELGIUM

SOURCE: RADIATION-PHYSICS-AND-CHEMISTRY. AUG 1997; 50 (2) : 149-153

ABSTRACT: After radiation sterilization, it is always necessary to demonstrate that any products formed in the irradiation are not harmful. The amounts of products formed in the gamma-irradiation of solid samples may be so small, that standard toxicity tests could be ineffective. Hence, analysis of the final products in the radiosterilized solid samples might be required. In this work, some chloramphenicol degradation products that are unique to radiolysis, i.e. different from the normal degradation products, were detected. (C) 1997 Elsevier Science Ltd.