1: Curr. Med. Chem. 2007;14(7):745-57.

The effect of ageing on cytochrome p450 enzymes: consequences for drug
biotransformation in the elderly.

Wauthier V, Verbeeck RK, Calderon PB.

Unité PMNT, Ecole de Pharmacie, Université catholique de Louvain. 73, avenue E.
Mounier, 1200 Bruxelles, Belgium.

Ageing is an aggravating factor leading to alterations in the biotransformation
of drugs, and therefore their therapeutic efficacy and safety. In this review we
discuss the influence of ageing on drug metabolizing enzymes in male Wistar rats.
We report that drug metabolizing enzymes can be affected by ageing either by
post-translational modifications or by transcriptional modifications. The
post-translational modifications could be due to an increase of oxidative stress
during ageing. Although it is now well established that transcriptional
modifications are due to a change in the GH secretion profile in senescent rats,
the intracellular mechanisms underlying these modifications are still unclear. In
addition to the strong decrease in the activity of the main CYPs of male rats, we
discuss the potential consequences on human drug metabolism in the elderly.

Publication Types: 
    Review

PMID: 17346160 [Pubmed - indexed for MEDLINE]

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