1. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5060-2. Epub 2009 Jul 10.

Synthesis and antitumor evaluation of
8-phenylaminopyrimido[4,5-c]isoquinolinequinones.

Vásquez D, Rodríguez JA, Theoduloz C, Verrax J, Calderon PB, Valderrama JA.

Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306,
Santiago, Chile.

A series of 8-phenylaminopyrimido[4,5-c]isoquinoline-7,10-quinone derivatives
were prepared by regioselective amination reaction of
pyrimido[4,5-c]isoquinoline-7,10-quinones with arylamines in the presence of a
Lewis acid catalyst. Preliminary evaluation of the members of the series against 
cancer cell lines and assays of activation of their cytotoxic activity on K562
cells with ascorbic acid are reported.

PMID: 19631536 [PubMed - in process]