1. Gut Pathog.;1(1):23. [Epub ahead of print] Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes. Van de Velde S, Carryn S, Van Bambeke F, Hill C, Tulkens PM, Sleator RD. ABSTRACT: While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem. PMCID: PMC2801671 PMID: 20003484 [PubMed - as supplied by publisher]