1: Biomed Pharmacother 1997;51(10):464-8

Anti-HIV activity of N-1-adamantyl-4-aminophthalimide.

Van Derpoorten K, Balzarini J, De Clercq E, Poupaert JH

Ecole de Pharmacie, Faculte de Medecine, Universite Catholique de Louvain, Bruselles, Belgium.

The discovery of new leads acting via novel modes of action in the treatment of the human immunodeficiency virus (HIV), the causative agent of AIDS, remains a challenge. Along this line we synthesized and evaluated a series of N-substituted 4-aminophthalimides which were designed according to the models of thalidomide, phenytoin (PHT) and ameltolide. From a series of 24 compounds only N-1-adamantyl-4-aminophthalimide was endowed with anti-HIV-1 and -HIV-2 activity in CEM cell cultures.

PMID: 9863507, UI: 99080875