1: J Controlled Release 1998 Aug 14;54(3):243-50
Transdermal permeation of neutral molecules by skin electroporation.
Vanbever R, Leroy MA, Preat V
Unite de pharmacie galenique, Ecole de pharmacie, Universite catholique
de Louvain, Brussels, Belgium.
Electroporation of skin has recently been shown to enhance transport of
charged molecules across skin by up to four orders of magnitude. This study
demonstrates that high-voltage pulses can also increase transdermal permeation
of two neutral model solutes, i.e. mannitol and water, up to 100-fold.
The elevated flux results from the persistent increase in skin permeability
following electroporation, rather than from electro-osmosis during pulsing.
Control on transport was achieved by controlling the electrical parameters
of the pulse, i.e. the pulse voltage, time constant and number.
PMID: 9766244, UI: 98439381