1: Br J Nutr. 2008 Feb;99(2):254-61. Epub 2007 Aug 22.

Physiological effects of dietary fructans extracted from Agave tequilana Gto. and
Dasylirion spp.

Urías-Silvas JE, Cani PD, Delmée E, Neyrinck A, López MG, Delzenne NM.

Unidad de Biotecnología e Ingeniería Genética de Plantas, CINVESTAV-IPN Unidad
Irapuato, A.P. 629, Irapuato, Gto., 36500, México.

Recent data reported that inulin-type fructans extracted from chicory roots
regulate appetite and lipid/glucose metabolism, namely, by promoting
glucagon-like peptide-1 (GLP-1) production in the colon. The Agave genus growing 
in different regions of Mexico also contains important amounts of original
fructans, with interesting nutritional and technological properties, but only few
data report their physiological effect when added in the diet. Therefore, we
decided to evaluate in parallel the effect of supplementation with 10 % agave or 
chicory fructans on glucose and lipid metabolism in mice. Male C57Bl/6J mice were
fed a standard (STD) diet or diet supplemented with Raftilose P95 (RAF), fructans
from Agave tequilana Gto. (TEQ) or fructans from Dasylirion spp. (DAS) for 5
weeks. The body weight gain and food intake in mice fed fructans-containing diets
were significantly lower than the ones of mice fed the STD diet, TEQ leading to
the lowest value. Serum glucose and cholesterol were similarly lower in all
fructans-fed groups than in the STD group and correlated to body weight gain.
Only RAF led to a significant decrease in serum TAG. As previously shown for RAF,
the supplementation with agave fructans (TEQ and DAS) induced a higher
concentration of GLP-1 and its precursor, proglucagon mRNA, in the different
colonic segments, thus suggesting that fermentable fructans from different
botanical origin and chemical structure are able to promote the production of
satietogenic/incretin peptides in the lower part of the gut, with promising
effects on glucose metabolism, body weight and fat mass development.


PMID: 17711612 [PubMed - indexed for MEDLINE]

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