1: Bioorg Med Chem Lett. 2008 Jul 15;18(14):4163-7. Epub 2008 May 24. 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors. Urbach A, Muccioli GG, Stern E, Lambert DM, Marchand-Brynaert J. Unité de chimie organique et médicinale, Université catholique de Louvain, Bâtiment Lavoisier, Place Louis Pasteur n degrees 1, 1348 Louvain-la-Neuve, Belgium. A series of novel 2-azetidinones (beta-lactams) bearing short alkenyl chains at C3 and N1 have been prepared and evaluated in vitro as inhibitors of human FAAH. Compound 9c (1-(4'-pentenoyl-3-(4'-pentenyl)-2-azetidinone)) featured an IC(50) value of 4.5 microM and a good selectivity for FAAH versus MGL. PMID: 18547805 [PubMed - in process] Related Links Synthesis and evaluation of N1/C4-substituted beta-lactams as PPE and HLE inhibitors. [Bioorg Med Chem. 2004] PMID:14697778 Stereoselective Synthesis of 3-Substituted 4-(Formyloxy)-2-azetidinones by the Unusual Baeyer-Villiger Reaction of beta-Lactam Aldehydes. Scope and Synthetic Applications. [J Org Chem. 1996] PMID:11667860 Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate. [Br J Pharmacol. 2005] PMID:15895107 An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase. [Bioorg Med Chem Lett. 1998] PMID:9871570 Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. [Biochemistry. 2007] PMID:17949010