1: Bioorg Med Chem Lett. 2008 Jul 15;18(14):4163-7. Epub 2008 May 24.

3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors.

Urbach A, Muccioli GG, Stern E, Lambert DM, Marchand-Brynaert J.

Unité de chimie organique et médicinale, Université catholique de Louvain,
Bâtiment Lavoisier, Place Louis Pasteur n degrees 1, 1348 Louvain-la-Neuve,
Belgium.

A series of novel 2-azetidinones (beta-lactams) bearing short alkenyl chains at
C3 and N1 have been prepared and evaluated in vitro as inhibitors of human FAAH. 
Compound 9c (1-(4'-pentenoyl-3-(4'-pentenyl)-2-azetidinone)) featured an IC(50)
value of 4.5 microM and a good selectivity for FAAH versus MGL.


PMID: 18547805 [PubMed - in process]

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