ARTICLE AUTHOR: Tilquin-B; Rollmann-B

REPRINT AUTHOR: Tilquin, B; UNIV CATHOLIQUE LOUVAIN; ECOLE PHARM, UNITE CHAM 7230, AV E MOUNIER 72; B-1200 BRUSSELS; BELGIUM

SOURCE: JOURNAL-DE-CHIMIE-PHYSIQUE-ET-DE-PHYSICO-CHIMIE-BIOLOGIQUE. JAN 1996; 93 (1) : 224-230

ABSTRACT:

The radiation treatment of bulk quantities with the transport system causes special difficulties like reliable dosimetry, dose-effect relationship, homogeneity of dose distribution, allowable ratio between the maximum and the minimum doses, modified atmosphere packaging,... All irradiated drugs undergo flavour and color changes, it is important to continue the collection of radiolytic by products and the investigations about the chemistry of these products acid to expand the toxicological studies. Improvement of microbiological safety, shelflife extension and replacement of chemical treatment for heat sensitive drug, are some reasons for radiosterilization!