1: Br J Anaesth 1995 Jan;74(1):46-9
Propofol pharmacokinetics in children with biliary atresia.
Raoof AA, van Obbergh LJ, Verbeeck RK
School of Pharmacy, Brussels, Belgium.
We studied the pharmacokinetics of an i.v. bolus dose of propofol 2.5-3.0
mg kg-1 in eight children (age 4-24 months) with biliary atresia and in
six control (ASA I) children (age 11-43 months). Blood samples were obtained
for 4 h after administration of propofol. Blood concentrations of propofol
were measured by high pressure liquid chromatography. Systemic clearance
of propofol (CI) and volume of distribution at steady state (Vss) showed
a highly significant correlation with body weight. Propofol CI and Vss,
normalized for body weight, were similar in children with biliary atresia
(mean 37.5 (SD 8.3) ml min-1 kg-1 and 3.5 (1.6) litre kg-1, respectively)
compared with control children (38.7 (6.8) ml min-1 kg-1 and 2.4 (0.8)
litre-1 kg-1, respectively). We conclude that in children with biliary
atresia the pharmacokinetics of propofol are similar to those of healthy
children.
PMID: 7880705, UI: 95186342