TI:  Administration de medicaments et de genes par electrotransfert.
[Drug and gene delivery using electrotransfer]
AU:  Preat,-V
AD:  Universite catholique de Louvain, Unite de pharmacie galenique, Avenue Mounier, 73 UCL 7320, B 1200 Bruxelles.
SO:  Ann-Pharm-Fr. 2001 Jul; 59(4): 239-44
JN:  Annales-pharmaceutiques-francaises
PY:  2001
AB:  The use of a low intensity current (iontophoresis) and high voltage pulses (electroporation which permeabilizes lipid bilayers) has a potential for the administration of conventional and biotechnology-produced drugs. Iontophoresis and electroporation enhance transdermal delivery of drugs, including peptides and oligonucleotides. Electrochemotherapy, i.e., combination of a systemic or local delivery of a non-permeant cytostatic drug with electroporation, kills locally tumor cells. Recently, it has been shown that the local injection of a plasmid before electroporation increases significantly gene transfection. Hence, electrotransfer is a promising alternative for drug and gene delivery.