TI: Administration de medicaments et de genes par electrotransfert.
[Drug and gene delivery using electrotransfer]
AU: Preat,-V
AD: Universite catholique de Louvain, Unite de pharmacie galenique,
Avenue Mounier, 73 UCL 7320, B 1200 Bruxelles.
SO: Ann-Pharm-Fr. 2001 Jul; 59(4): 239-44
JN: Annales-pharmaceutiques-francaises
PY: 2001
AB: The use of a low intensity current (iontophoresis) and high
voltage pulses (electroporation which permeabilizes lipid bilayers) has
a potential for the administration of conventional and biotechnology-produced
drugs. Iontophoresis and electroporation enhance transdermal delivery of
drugs, including peptides and oligonucleotides. Electrochemotherapy, i.e.,
combination of a systemic or local delivery of a non-permeant cytostatic
drug with electroporation, kills locally tumor cells. Recently, it has
been shown that the local injection of a plasmid before electroporation
increases significantly gene transfection. Hence, electrotransfer is a
promising alternative for drug and gene delivery.