Unsymmetrical diaryl ketones from electron-rich heterocyclic arenes.     Poupaert, Jacques H.; Depreux, Patrick; McCurdy, Christopher R.    School of Pharmacy, Universite Catholique de Louvain,  Brussels,  Belg.    Monatshefte fuer Chemie  (2003),  134(6),  823-830.  CODEN: MOCMB7  ISSN: 0026-9247.  Journal  written in English.    CAN 140:27776    AN 2003:620417    CAPLUS  

Abstract

AlCl3-mediated chlorocarbonylation of a first arene by oxalyl chloride followed by in situ Friedel-Crafts acylation of a second electron-rich arene expeditiously provides, in a one-pot procedure, either sym. or unsym. benzophenones, i.e., I (X = O, S; R = Me, benzyl) and II (X = O, S, CH2; R = H, Me; Y = H, Cl), with yields ranging from 17-52%.  Best results are obtained when the more activated substrate is used as the second arene.  Another advantage is that the resultant benzophenone ppts. from the reaction mixt. allowing facile workup.  
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Indexing -- Section 28-7  (Heterocyclic Compounds (More Than One Hetero Atom)  
Section cross-reference(s): 27