1: Int Immunopharmacol. 2009 Jun;9(6):767-73. Epub 2009 Mar 13.

Dietary supplementation with chitosan derived from mushrooms changes
adipocytokine profile in diet-induced obese mice, a phenomenon linked to its
lipid-lowering action.

Neyrinck AM, Bindels LB, De Backer F, Pachikian BD, Cani PD, Delzenne NM.

Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug
Research Institute, Université catholique de Louvain, PMNT7369 73 av. Mounier,
B-1200 Brussels, Belgium.

Recent data reported that chitosan reduces high-fat (HF) diet-induced obesity in 
mice without describing the metabolic consequences of such an effect. The aim of 
this study was to investigate the capacity of chitosan derived from edible
mushrooms to modify adipocytokine levels and to assess the relevance of this
effect on the development of fat mass, and on glucose and lipid metabolism in
obese mice. Mice were fed a HF diet or a HF diet supplemented with 5% fungal
chitosan for ten weeks. HF-induced hypertriglyceridaemia, fasting
hyperinsulinaemia and fat accumulation in liver, muscle and white adipose tissue 
(WAT) were reduced after chitosan treatment. The higher lipid content in the
caecum following treatment with chitosan suggested that this dietary fiber
reduced lipid absorption. We postulated that the lower triglyceridaemia observed 
upon chitosan treatment could also be the result of the lower FIAF
(fasting-induced adipose factor) expression observed in visceral adipose tissue. 
IL-6, resistin and leptin levels decreased in the serum after chitosan
supplementation. We conclude that fungal chitosan counteracts some inflammatory
disorders and metabolic alterations occurring in diet-induced obese mice since it
decreases feed efficiency, fat mass, adipocytokine secretion and ectopic fat
deposition in the liver and the muscle.


PMID: 19286482 [PubMed - in process]

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