1: Int Immunopharmacol. 2008 Oct;8(10):1423-32. Epub 2008 Jun 20.

Immunomodulatory properties of two wheat bran fractions - aleurone-enriched and
crude fractions - in obese mice fed a high fat diet.

Neyrinck AM, De Backer F, Cani PD, Bindels LB, Stroobants A, Portetelle D,
Delzenne NM.

Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Université
catholique de Louvain, Brussels, Belgium.

Several data suggest that fermentable dietary fibers could play a role in the
control of obesity and associated metabolic disorders. In mice, dietary fructans,
which are extensively fermented in caeco-colon by bifidobacteria, decrease fat
mass development and modulate gastrointestinal peptides involved in the control
of food intake (namely glucagon-like peptide (GLP)-1). The aim of this study was 
to compare the effect of two cereal bran fractions isolated from wheat -
aleurone-enriched and crude fractions - in a nutritional model of obesity. In a
first experiment, we confirmed that 2 weeks of treatment with a high fat (HF)
diet is sufficient to exhibit glucose intolerance and to increase adiposity in
mice. In the second experiment, mice were fed a HF or a HF diet enriched with 10%
wheat bran fractions during 3 weeks. None of the wheat bran fractions modified
body weight, adipose tissue mass, glucose or lipid homeostasis. Wheat bran
fractions increased bifidobacteria and lactobacilli in the caecal content without
any effect on caecal enlargement and on GLP-1 precursor expression in the colon. 
Furthermore, wheat bran fractions decreased circulating interleukin 6 (IL-6) and 
CD68 mRNA in the visceral adipose tissue, suggesting a decrease in
recruited-tissue macrophages. We propose that specific and early immunomodulatory
properties of cereal products with prebiotic properties, may occur in obese mice 
independently of extensive gut fermentation.


PMID: 18687304 [PubMed - indexed for MEDLINE]

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