1: Org Lett. 2003 Oct 2;5(20):3599-602. Versatile access to benzhydryl-phenylureas through an unexpected rearrangement during microwave-enhanced synthesis of hydantoins. Muccioli GG, Wouters J, Poupaert JH, Norberg B, Poppitz W, Scriba GK, Lambert DM. Unite de Chimie Pharmaceutique et de Radiopharmacie, Ecole de Pharmacie, Faculte de Medecine, Universite catholique de Louvain, Avenue E. Mounier 73, UCL-CMFA 7340, B-1200 Bruxelles, Belgium. [reaction: see text] A new access to benzhydryl-phenylureas is described. These new interesting urea derivatives were obtained by reaction of substituted benzils with substituted phenylureas under microwave irradiation. Phenylthiourea, when reacted with benzil, gave 3-phenyl-thiohydantoin. Moreover, benzylurea, as phenethylurea, gave the corresponding 3-substituted hydantoin derivatives, demonstrating that only phenylurea derivatives can result in benzhydryl-phenylureas under the applied conditions. This new reaction proved to be an easy access to substituted 1-benzhydryl-3-phenyl-ureas. PMID: 14507182 [PubMed - in process]