1: Int Orthop 1995;19(3):157-61
Biodegradable implants for potential use in bone infection. An in vitro
study of antibiotic-loaded calcium sulphate.
Mousset B, Benoit MA, Delloye C, Bouillet R, Gillard J
Universite Catholique de Louvain, Unite de Parmacie, Bruxelles, Belgium.
Local antibiotic therapy by diffusion from plaster of Paris beads has proved
promising in bone surgery. Sustained local delivery depends on thermostability,
so we tested the antibacterial activity of 11 antibiotic solutions after
storage at 37 degrees C using a microbiological method. Cephalosporins
and penicillins were unstable, but aminoglycosides remained fully stable
with 100% activity after 2 weeks. About 60% of the initial bactericidal
activity of quinolone, glycopeptides and sodium fusidate were still detectable
after 2 weeks. Release of these antibiotics from plaster of Paris beads
was evaluated in vitro. Even those in the same family differed in their
release rate. Plaster beads with sodium fusidate were the most effective
association. A therapeutic level of glycopeptides, aminoglycosides and
amoxicillin was leached for about 3 weeks. Cephalosporins and sodium amoxicillin
were released in 2 to 3 days, and quinolone beads were too brittle to be
used. Plaster of Paris, which is cheap, biocompatible and biodegradable,
is an excellent carrier for sodium fusidate, aminoglycosides and glycopeptides.
PMID: 7558491, UI: 96056053