1: Skin Pharmacol Appl Skin Physiol.  2003 Jan-Feb;16(1):18-27.  

In vivo tolerance assessment of skin after insertion of subcutaneous and
cutaneous microdialysis probes in the rat.

Mathy FX, Denet AR, Vroman B, Clarys P, Barel A, Verbeeck RK, Preat V.

Unite de Pharmacie Galenique, Metabolisme, Nutrition et Toxicologie, Universite
Catholique de Louvain, Belgium.

The purpose of the study was to evaluate the trauma induced by insertion of the
linear microdialysis probe in the subcutaneous and dermal tissue in the rat and
to check if the microdialysis probe insertion affects transdermal drug delivery.
Non-invasive bioengineering methods (TEWL, Laser Doppler Velocimeter,
Chromameter) as well as histology were combined to characterize these effects.
The results showed that the dermal and subcutaneous insertion of microdialysis
probes did not change skin permeability, blood flow and color, confirming the
safety of this technique. The probe depth did not influence the trauma. No
significant physical damage after probe insertion was noticed. Thus, the present
work validates the use of microdialysis in dermatopharmacokinetics studies after
topical or systemic drug delivery. Copyright 2003 S. Karger AG, Basel

PMID: 12566825 [PubMed - indexed for MEDLINE]