1: J Control Release. 2006 Mar 10;111(1-2):47-55. Epub 2006 Feb 7. 

Intestinal uptake and biodistribution of novel polymeric micelles after oral
administration.

Mathot F, van Beijsterveldt L, Preat V, Brewster M, Arien A.

Universite Catholique de Louvain, Department of Pharmaceutical Technology,
Avenue E. Mounier 73 UCL 73.20, 1200 Brussels, Belgium.

To determine the fate of polymeric micelles after oral administration, we
investigated the possible transport of polymeric micelles across Caco-2
monolayers and their biodistribution in rats after per os administration of
[(14)C]-labelled mmePEG(750)P(CL-co-TMC) micelles containing risperidone (BCS
Class II drug). mmePEG(750)P(CL-co-TMC) was able to cross Caco-2 monolayer via a
saturable transport mechanism. The oral bioavailability of the polymer was 40%.
Polymeric micelles based on mmePEG(750)P(CL-co-TMC) showed very low clearance by
the reticuloendothelial system (RES) and a renal excretion. A sustained release
of risperidone was observed.

PMID: 16460829 [PubMed - in process]