1: Appl Radiat Isot 1996 Nov-Dec;47(11-12):1663-7
In vivo EPR: an effective new tool for studying pathophysiology, physiology
and pharmacology.
Mader K, Gallez B, Swartz HM
Department of Radiology, Dartmouth Medical School, Hanover, NH 03755, USA.
The development of spectrometers working at lower frequencies with improved
resonators now permits the routine use of non-invasive EPR spectroscopy
in vivo. The capabilities of EPR spectra to reflect environmental conditions,
combined with the use of paramagnetic materials as selective non-toxic
labels, has led to increasingly widespread and productive applications
of the technique to complex problems involving physiology, pharmacology
and pathophysiology. Some of the especially promising applications in which
EPR techniques uniquely appear to provide valuable information are illustrated,
including the measurement of oxygen and oxygen gradients, monitoring of
the metabolism of xenobiotics, monitoring pharmacokinetics of drugs, measurement
of perfusion, measurement of pH, recognition and labeling of receptors,
and characterization of drug releasing systems.
Publication Types:
Review
Review, tutorial
PMID: 9022207, UI: 97174479