ARTICLE AUTHOR: Lemoine-D; Francotte-M; Preat-V

REPRINT AUTHOR: Preat, V; UNIV CATHOLIQUE LOUVAIN; UNITE PHARM GALEN, AVE EMMANUEL MOUNIER 73-20; B-1200 BRUSSELS; BELGIUM

SOURCE: STP-PHARMA-SCIENCES. JAN-FEB 1998; 8 (1) : 5-18

ABSTRACT:

This article reviews intracranial vaccination, with particular emphasis on fundamental concepts and vaccine development. The lymphoid tissue of the upper respiratory tract is described in terms of morphology, histology and cell phenotype. The hypothetical mechanisms of antigen sampling and pathways eliciting immune responses are discussed. The literature describing practical approaches to nasal vaccine formulation are summarized.