Oligofructose modulates lipid metabolism alterations induced by a fat-rich diet in rats.
Kok NN, Taper HS, Delzenne NM
Departement des Sciences Pharmaceutiques, Universite Catholique de Louvain, Brussels, Belgium.
The aim of this study was to test the hypothesis that non-digestible
fructans, namely oligofructose (OFS), are able to decrease post-prandial
lipaemia in rats fed a high-fat diet composed of 10% lard, 4% corn oil
and 0.15% cholesterol. Male Wistar rats were divided into three groups:
group 1 was fed a standard low-fat diet (AO4), group 2 received the high-fat
diet (HF) and group 3 received 10% (w/w) OFS in the HF diet (HF-OFS) for
3 weeks. The OFS supplementation reduced post-prandial triglyceridaemia
by more than 50%, compared to both AO4 and HF groups. It also protected
rats against the increase in free cholesterol serum level induced by the
HF diet. The OFS did not prevent the HF-induced hepatic accumulation of
triglycerides, phospholipids and cholesterol; however, histochemical analysis
showed smaller lipid droplets in the liver of HF-OFS rats as compared to
HF rats. Our results suggest that, when given in HF diet, OFS decreases
serum triglycerides through an extra-hepatic event, namely by enhancing
triglyceride-rich lipoprotein catabolism.
PMID: 9526834, UI: 98186029