1: J Pharm Biomed Anal  2002 Jan 15;27(3-4):457-65 

Comparative HPLC enantioseparation of new chiral hydantoin derivatives on three
different polysaccharide type chiral stationary phases.

Kartozia I, Kanyonyo M, Happaerts T, Lambert DM, Scriba GK, Chankvetadze B.

Institute of Pharmaceutical Chemistry, University of Munster, Hittorfstrasse
58-62, 48149 Munster, Germany.

The enantioseparation of eighteen new chiral hydantoin derivatives was studied
on three different polysaccharide type chiral stationary phases (CSP) Chiralpak
AD, Chiralcel OD and Chiralcel OJ in the normal-phase HPLC mode. Chiralpak AD
material exhibited the most universal chiral resolving ability and allowed the
enantioseparation of 17 out of 18 compounds followed by Chiralcel OD (10
enantioseparations of 12 tested compounds) and Chiralcel OJ (eight
enantioseparation from 13 tested analytes). Some complementary separations were
observed and all of 18 compounds could be resolved at least with one of the
three chiral CSP under the conditions of this study. With regard to the
structure of the analytes, bulky electron rich substituents at C5 of the
hydantoin nucleus appear to favor stereoselective interactions.

PMID: 11755747 [PubMed - indexed for MEDLINE]