3-Alkyl-(5,5'-diphenyl)imidazolidineiones as new cannabinoid receptor ligands.

Kanyonyo M, Govaerts SJ, Hermans E, Poupaert JH, Lambert DM

Unite de Chimie Pharmaceutique et de Radiopharmacie, Universite Catholique de Louvain, Bruxelles, Belgium.

Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists.

PMID: 10465552, UI: 99393243