1. Cancer Lett. 2010 Jul 28;293(2):213-9. Epub 2010 Feb 9.

Captopril and S-nitrosocaptopril as potent radiosensitizers: Comparative study
and underlying mechanisms.

Jordan BF, Peeterbroeck J, Karroum O, Diepart C, Magat J, Grégoire V, Gallez B.

Biomedical Magnetic Resonance Unit, Louvain Drug Research Institute, Université
Catholique de Louvain, B-1200 Brussels, Belgium.

In an effort to improve the issue of radiotherapy treatments, we tested whether
S-nitrosocaptopril, a molecule combining a NO donor and an angiotensin converting
enzyme inhibitor (ACE inhibitor), could temporarily improve the hemodynamic
status of experimental tumors. We monitored the effect of S-nitrosocaptopril in
TLT tumors using non rinvasive magnetic resonance techniques. We identified a
time window during which tumor oxygenation was improved, as a result of a
combined effect on tumor blood flow and oxygen consumption. Consequently, the
administration of S-nitrosocaptopril contributed to the increase in efficacy of
radiation therapy, an effect that was not observed with captopril alone.
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

PMID: 20144849 [PubMed - indexed for MEDLINE]