1: Bioorg Med Chem Lett. 2007 Nov 1;17(21):5758-62. Epub 2007 Aug 28. Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif l-Lys-d-Ala-d-Ala for use in a vancomycin biosensor. Hernout O, Berthoin K, Delattre I, Tulkens PM, Carryn S, Marchand-Brynaert J. Unité de Chimie organique et médicinale, Université catholique de Louvain, Bâtiment Lavoisier, Place L. Pasteur 1, B-1348 Louvain-la-Neuve, Belgium. Four small molecular receptors of vancomycin have been designed to make part of a novel biosensor device based on the FTIR-ATR detection: N-Boc (2a) or N-Ac (2b)-6-aminocaproyl-d-Ala-d-Ala and N-Boc (3a) or N-Ac (3b)-6-aminocaproyl-d-Ala-d-Ser. Using an original microbiological approach to assess the competition of compounds with the natural target of vancomycin in bacteria, EC(50) values of 6.3-8.0x10(-5)M (2a-b) and 7.1-9.3x10(-4)M (3a-b) were determined. Vancomycin:2b complex was characterized by MS. PMID: 17855088 [PubMed - in process] Related Links Conformational analysis of bacterial cell wall peptides indicates how particular conformations have influenced the evolution of penicillin-binding proteins, beta-lactam antibiotics and antibiotic resistance mechanisms. [J Mol Recognit. 2002] PMID:12203837 Cooperativity between non-polar and ionic forces in the binding of bacterial cell wall analogues by vancomycin in aqueous solution. [J Antibiot (Tokyo). 1995] PMID:7592024 Binding studies of vancomycin to the cytoplasmic peptidoglycan precursors by affinity capillary electrophoresis. [Anal Chem. 1994] PMID:8080114 Antibiotic activities and affinities for bacterial cell wall analogue of N-demethylvancomycin and its derivatives. [J Antibiot (Tokyo). 1998] PMID:9766467 Affinity adsorbents for the vancomycin group of antibiotics. [Biotechnol Appl Biochem. 2000] PMID:10669398