1: J Control Release. 2006 Apr 10;111(3):316-24. Epub 2006 Feb 28.

New self-assembled nanogels based on host-guest interactions: characterization
and drug loading.

Gref R, Amiel C, Molinard K, Daoud-Mahammed S, Sebille B, Gillet B, Beloeil JC,
Ringard C, Rosilio V, Poupaert J, Couvreur P.

School of Pharmacy, Universite Paris Sud, UMR CNRS 8612, 5 Rue J. B. Clement,
92290 Chatenay Malabry, France. ruxanda.gref@cep.u-psud.fr

We show here, for the first time, that two neutral polymers may completely
associate together in water to spontaneously form supramolecular nanoassemblies
(nanogels) of spherical shape. The cohesion of these stable structures of about
200 nm is based upon a "lock and key" mechanism: inclusion complexes are formed
between the hydrophobic alkyl chains grafted on a polysaccharide (dextran) and
the molecular cavities contained in a poly-cyclodextrin polymer. Production
yields reached 95%. It was established that all the alkyl chains were included
within the cyclodextrins' cavities in these nanoassemblies. The multivalent
character of the interactions between the two polymers ensures the stability of
the nanoassemblies. Moreover, empty cyclodextrin units remained accessible for
the inclusion of compounds of interest such as benzophenon or tamoxifen.

PMID: 16504334 [PubMed - in process]

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