ARTICLE AUTHOR: Gibella-M; Crucq-AS; Tilquin-B; Stocker-P; Lesgards-G; Raffi-J

REPRINT AUTHOR: Tilquin, B; Univ Catholique Louvain; Unite Anal Chim & Physicochim Medicaments; UCL 72-30,Ave E Mounier 72; B-1200 Brussels; Belgium

SOURCE: RADIATION-PHYSICS-AND-CHEMISTRY. MAR 2000; 58 (1) : 69-76

ABSTRACT:

Five antibiotics belonging to the cephalosporins and penicillins groups have been irradiated: anhydrous ampicilline acid, amoxicilline acid trihydrate, cefuroxime sodium salt, cloxacilline sodium salt monohydrate and ceftazidime pentahydrate. ESR studies have been carried out, showing the influence of irradiation and storage parameters on the nature and concentration of the free radicals trapped. These results may be used to detect an irradiation treatment on such pharmaceuticals. (C) 2000 Elsevier Science Ltd. All rights reserved.