J Nutr 2000 Jul;130(7):1831-3
Free radicals in licorice-flavored sweets can Be detected noninvasively
using low frequency electron paramagnetic resonance after oral administration
to mice.
Gallez B, Baudelet C, Debuyst R
Laboratory of Medicinal Chemistry and Radiopharmacy, Universite Catholique
de Louvain, B-1200 Brussels, Belgium.
The observation of the fate of free radicals coming from food after oral
administration could be important in evaluating their reactivity in vivo.
The aim of this study was to demonstrate that it is feasible to detect
directly in vivo free radicals coming from food with the use of low frequency
electron paramagnetic resonance (EPR) spectroscopy. Because polyphenols
are easily
oxidized into stable radicals, we assumed that these radicals could be
detected in food. We chose licorice, which contains several types of polyphenols.
The presence of free radicals was demonstrated in licorice-flavored sweets.
Using low frequency EPR spectroscopy, we detected these free radicals directly
and noninvasively after oral administration to mice. These radicals were
rather stable in the guts of the mice. This study is the first report demonstrating
noninvasively the presence of free radicals in vivo coming from food.
PMID: 10867059, UI: 20327770